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2011 Articles

April 18, 2011

Date Released: 18 April 2011
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Leukemia Drug is Just One of Many Chemo Drugs in Short Supply
Plain Dealer - Apr 18, 2011
University Hospitals' Dr. John Letterio said medical centers don't get advanced notice of manufacturing delays, but should. This is a critical issue, he said, because cancer patients get chemotherapy on specific schedules. A delay in treatment due to ...

In the Works: Decoding Tumors in Search of More Effective Cancer Treatments
Los Angeles Times - Apr 17, 2011
The approach is "skinny and deep," adds Dr. Charis Eng, director of the Genomic Medicine Institute at the Cleveland Clinic, "and that's a good thing." White is partnering with several doctors who can use his sequences to advance their research. ...


Case CCC Scientific Series: Immunology

The next installment of the Case CCC Scientific Series is scheduled for Thursday, April 21 from 4-6:30 pm in Wolstein Auditorium (WRB 1-413). Drs. Anton Gorbachev, Neetu Gupta and Alex Huang will discuss the topic of Immunology:

  • Anton Gorbachev, PhDDown-Regulation of CXCL9/Mig Expression in the Tumor Microenvironment as a Result of Immunoediting
  • Neetu Gupta, PhDA Novel Signaling Link Between Ezrin and JNK Regulates Antigen-Dependent B Cell Survival
  • Alex Huang, MD, PhDMeasuring Immune Surveillance in Tissue Microenvironment

Presentations will be followed by a short reception. All are encouraged to attend.

Cancer Center Seminar Series: Development of a Prophylactic Breast Cancer Vaccine

Friday, April 22
12-1 pm
Frohring Auditorium - BRB 105

Please join us Friday, April 22 at the next Cancer Center Seminar Series featuring Vincent K. Tuohy, PhD. Dr. Tuohy, Professor of Immunology, Molecular Medicine, and Pathology at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University and Staff in the Department of Immunology at the Cleveland Clinic, will present Development of a Prophylactic Breast Cancer Vaccine.

Dr. Vincent K. Tuohy received his PhD in the Department of Pathology at the State University of New York, and completed his post-graduate training at Harvard Medical School. During his post-graduate training, Dr. Tuohy studied the immune response to the highly hydrophobic myelin proteolipid protein (PLP) and showed how an immune response to PLP was capable of inducing severe autoimmune demyelination of the central nervous system similar to what occurs in human multiple sclerosis. For his research efforts, Dr. Tuohy received the Harry Weaver Award from the National Multiple Sclerosis Society, the Peter W. Lampert Prize from the Society for Experimental Neuropathology, and the FIRST Award from the National Institute of Neurological Disorders and Stroke at the National Institutes of Health.

Dr. Tuohy was recruited to the Cleveland Clinic in 1989 where he has extended his initial work on central nervous system autoimmunity by developing and characterizing autoimmune rodent models for deafness, heart failure, cystitis, prostatitis, ovarian failure, and breast failure. The ovarian and breast failure mouse models have been particularly useful in serving as novel cancer vaccination strategies for providing highly effective prevention and treatment of breast cancer and ovarian cancer. Dr. Tuohy serves as a consultant for the National Institutes of Health and the National Multiple Sclerosis Society, serves on the editorial board for several science journals, has trained over 20 postdoctoral fellows and graduate students, and has published over 85 manuscripts.

Case CCC Annual Scientific Retreat

The Case CCC Annual Scientific Retreat will be July 8-9 at Corporate College East. Details will be posted soon.


Pilot Project Grants: American Cancer Society IRG Awards

The Case CCC is currently accepting applications for American Cancer Society Institutional Research Grant (IRG) awards. Pilot funding is available for projects in basic, clinical, prevention and control, behavioral, health services, and epidemiology cancer research with awards up to $30,000 for one-year cancer research projects that provide the basis for future independent grants.

IRG pilot project grants are intended to support independent, self-directed investigators early in their careers (assistant professor or equivalent). Applicants for the pilot project grants should be within 6 years of their first independent research or faculty appointment and eligible to apply for an independent national competitive research grant, but may not currently hold such a grant.

At the time of application, recipients of IRG pilot project grants must be citizens or noncitizen nationals of the United States or its possessions and territories, or must have been lawfully admitted to the United States for permanent residence at the time of application.

Instructions, frequently asked questions, and application forms are available at Contact Terri Daso, Cancer Center Administration (844-7252, for more information.

LOI Deadline: June 13
Application Deadline: July 5, 2011

Robert Wood Johnson Foundation Public Health Services and Systems Research Grant

The Robert Wood Johnson Foundation seeks to expand the evidence base for effective public health policy and practice through investment in Public Health Services and Systems Research (PHSSR). PHSSR examines the organization, financing and delivery of public health services within a community and determines the links between the quality and performance of the public health system and population health outcomes.

A web conference for interested applicants will be held April 27 at 3 pm. Registration is required.

Proposal Deadline: May 24


Message from Dr. David Wald, Scientific Director, Hematopoietic Stem Cell Core Facility
The Case Comprehensive Cancer Center is gathering information about anticipated research needs for the Hematopoietic Stem Cell Core Facility. Your responses will help us build a core facility that reflects the collective needs of cancer center members. Please visit and complete the short survey.

We appreciate your participation!



**All events are open to anyone interested in attending

April 18

Pathology Research Seminar
Claudio Soto, PhD
Professor, Neurology
University of Texas Medical Branch at Galveston
Topic: Infectious Proteins: Expanding the Prion Heresy
12 pm WRB 1-413

Physiology and Biophysics Seminar
William Pearce, PhD
Professor, Physiology
Associate Director, Center for Perinatal Biology
Loma Linda University
Topic: Functional Maturation of the Fetal Vasculature: A Tale of Calcium, Myosin, VEGF, and miRNA
4 pm SOM E501

April 19

Cancer Biology Fellow Seminar
Awad Jarrar, MD
Research Fellow, Kalady Lab
Cleveland Clinic
Topic: Studying Chemoresistance in Colorectal Cancer: From Molecular Pathways to Cancer Stem Cells
11 am NC1-202 Cleveland Clinic

Immunology Seminar
Neil Greenspan, MD, PhD
Professor, Pathology
Topic: Immunology, Evolution, and Logic: Reflections on Immunological Specificity
12 pm WRB 1-413

April 20

Developmental Therapeutics Program (DTP) Meeting canceled

Hematology and Oncology Division Research Conference
Lalitha Nayak, MD
Fellow, Div. of Hem/Onc
Topic: Transcription Factor Kruppel-like Factor 2 (KLF2) Deficiency Promotes Platelet Hyperactivity and Vascular Thrombosis in Mice
8 am Lerner B-151

Immunology Invited Speaker Seminar Series
Clifford Harding, MD, PhD
Professor and Chair, Pathology
Topic: TLR Signaling and Regulation of Immune Responses by Mycobacterium Tuberculosis 
12 pm NC1-202 Cleveland Clinic

NCRM Lunch and Learn
Jed Johnson, PhD
Nanofiber Solutions
Topic: Next Generation 3D Cell Culture
12 pm WRB 2-136

Pathology Graduate Student Seminar
Lachelle Weeks
Gerson Lab, Div. of Hem/Onc
Topic: Loss of Uracil DNA Glysocylase (UDG) Potentiates Pemetrexed Cytotoxicity in Vitro and In Vivo
12 pm WRB 1-413

Cancer Imaging Program (CIP) Drug Delivery Focus Group Meeting
Drs. Vinod Labhasetwar, Eben Alsberg and Horst von Recum will present a brief synopsis of their research and current critical needs in the field of drug delivery
2:30 pm Wearn B-37

April 21

Cancer Center Scientific Series: Immunology
Anton Gorbachev, PhD
Topic: Down-Regulation of CXCL9/Mig Expression in the Tumor Microenvironment as a Result of Immunoediting
Neetu Gupta, PhD
Topic: A Novel Signaling Link Between Ezrin and JNK Regulates Antigen-Dependent B Cell Survival
Alex Huang, MD, PhD
Topic: Measuring Immune Surveillance in Tissue Microenvironment
4-6:30 pm WRB 1-413

April 22

Cancer Center Research in Progress Seminar canceled

Taussig Cancer Institute Grand Rounds canceled

Hematology/Oncology Fellows
Neal Meropol, MD
Professor, Medicine-Hematology/Oncology
Topic: Building a Successful Career in Clinical Research
8 am Wearn 137

Cancer Center Seminar Series
Vincent Tuohy, PhD
Professor, Immunology, Molecular Medicine, and Pathology
CWRU/Cleveland Clinic
Topic: Development of a Prophylactic Breast Cancer Vaccine
12 pm BRB 105

Case CCC Calendar

LRI Calendar


Breast Cancer Detection and Management: Issues for 2011
May 20
Hilton Cleveland East

Case CCC Annual Scientific Retreat
July 8-9
Details to follow


Midwest Blood Club 9th Annual Symposium
April 21-22
Cincinnati Children's Hospital Medical Center

2011 Clinical and Translational Research and Education Meeting: ACRT/SCTS Joint Annual Meeting
April 27-29
Omni Shoreham in Washington, DC

Cincinnati Cancer Symposium Series: 2011 Symposium on NF-κB, Cancer, Obesity, and Inflammation
May 1-4
Westin Hotel Cincinnati

4th International Symposium on Cancer Metastasis and the Lymphovascular System
May 12-14
New York City

2nd Annual Department of Medicine Research Day
May 16
12-5 pm
Wolstein Research Building auditorium and lobby

Race for the Place
June 5
Beachwood Place Mall

International Society for Stem Cell Research (ISSCR) Annual Meeting
June 15-18
Toronto, Canada

Cancer Health Disparities Summit 2011
July 13-15
Bethesda North Marriott Hotel in Rockville, Maryland

8th International Conference of the Society for Integrative Oncology: Innovating Integrative Oncology: New Science, New Solutions
November 10-12
InterContinental Hotel Cleveland


Avon Foundation Breast Cancer Research Program
Cycle 2 LOI Deadline: May 6
Cycle 2 Full Proposal Deadline: July 5

Ovarian Cancer Research Fund Program Project Development Grants
LOI Deadline: May 9

Ovarian Cancer Research Fund Liz Tilberis Scholars
LOI Deadline: May 9

Ovarian Cancer Research Fund Ann Schreiber Research Training Programs of Excellence
LOI Deadline: May 9

Uniting Against Lung Cancer 2011 Legacy Program for Advances in Lung Cancer Research
Deadline: August 17

Lustgarten Foundation Fall 2011: Basic Research Innovator Awards
Concept Proposal Deadline: September 14
Full Application Deadline: October 31

Translational Technology Concept Studies of Circulating Tumor and Endothelial Cells (CTC/CEC)
Deadline: Open

AACR Scholar-in-Training Awards - Other Conferences and Meetings
Deadline: Open

International Union Against Cancer (UICC) International Cancer Technology Transfer Fellowships
Application Deadline: Open

NCI Short-Term Scientist Exchange Program
Application Deadline: Open

James S. McDonnell Foundation Collaborative Activity Awards
Application Deadline: Open

NIH BULLETIN – Notices and Funding Opportunities

Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (Interagency U01)(PAR-11-203)

Produced by:
Gillian Irwin Todd
11100 Euclid Avenue, Wearn 149
Cleveland, Ohio 44106-5065
216-844-8317 phone
216-844-7832 fax


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