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March 2, 2015


Awards for Program Sponsored Project Grants from Case CCC Developmental Funds 

Last fall, the Cancer Center Executive Committee elected to promote scientific advancement of our eight scientific program by supporting a Request for Applications (RFA) for multi-investigator grant applications coming from the Programs. The Program Leaders were to select the most exciting proposal from their Program that met the criteria of being a multi-investigator effort with a high likelihood of leading to national funding. 

Projects were submitted in early December and reviewed by the Executive Committee in mid-January 2015. All principal investigators and their Program Leaders have been informed of the decisions, and we can now announce the selected projects: 

Cancer Imaging Program
cGMP PET Biomarker Research Program
Principal Investigator: Norbert Avril, MD
Co-Investigators: Yanming Wang, PhD; Zhenghong Lee, PhD; Raymond Muzic, PhD; Analisa DiFeo, PhD; Rodney Ellis, MD; Lisa Rogers, DO

Hematopoietic Diseases Program
Optimizing Allogeneic Transplant Outcomes Using Next Generation Sequencing 
Principal Investigator: Navneet Majhail, MD, MS
Co-investigators: Marcos DeLima, MD; Betty Ky Hamilton, MD; Basem William, MD; Jaroslaw Maciejewski, MD, PhD; Hideki Makishima, MD, PhD; Thomas LaFramboise, PhD

Molecular Oncology Program
Differential Lipid Metabolism Drives Self-Renewal in Glioblastoma
Co-Principal Investigators: J. Mark Brown, PhD and Justin D. Lathia, PhD

Breast Cancer Developing Program
Radiogenomic approach for predicting pathologic complete response in HER2+ breast cancers
Co-Principal Investigators:  Anant Madabhushi, PhD, Lyndsay Harris, MD
Co-investigators: Vinay Varadan, PhD; Donna Pletcha, MD; Hannah Gilmore, MD

All of the projects are quite exciting. I have been in contact with the investigators, and they are pursuing their projects with the hope that the Cancer Center will be able to provide support in a variety of ways as the projects mature. We will hear about these projects at the summer scientific retreat and will also have a fall scientific symposium. We expect to hear exciting things from each of the projects! 

Local Programming to Link Cancer Center Research to Ken Burns Documentary

As a precursor to the showing of the documentary,Ken Burns Presents Cancer- The Emperor of All Maladies, ideastream (90.3 WCPN, WVIZ/PBS and has embarked on a project to cover a myriad of cancer stories regionally. This program series will kickoff Friday, March 6 at 8:30 pm on the WVIZ-TV program, Ideas. The special ideastream series was initially planned to run through April, but the reporting team uncovered many vital stories to tell that programming has been extended into May. 

I am happy to report that our members will take center stage in this series, reporting news on the collaborative efforts at CWRU, Seidman and Cleveland Clinic.   

A schedule of the programming and times of coverage are available on the ideastream website. Ken Burns Presents Cancer- The Emperor of All Maladies, airs on WVIZ/PBS on March 30, March 31, and April 1 at 9 pm. 

I welcome your comments throughout the series, and encourage you to share the content through social media. If you would like to be a voice for the Cancer Center on any of the topics, please contact